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[8] The MHRA Drug Safety Update highlights that metformin interferes with calcium-dependent B12 absorption in the terminal ileum, and long-term use is associated with reduced serum B12 levels in a significant proportion of patients
"Antiepileptic drugs interact with folate and vitamin B12 serum levels" (PDF)
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It bypasses the blood-brain barrier via the olfactory and trigeminal pathways, achieving direct CNS delivery with minimal systemic exposure
Metabolic research focus: Examined in obese rodent studies for changes in weight gain patterns, fat oxidation, and markers associated with lipolysis and lipogenesis
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