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GLP-1 binds to its receptor (GLP-1R) on pancreatic -cell membranes, enhancing insulin secretion and gene expression via cyclic AMP (cAMP) and calcium-mediated signaling pathways [55, 56, 60,61,62]

A dose-response study of the most promising derivatives confirmed a high potency and duration of action with an ED50 below 2 nmol/kg (calculated as the delta area under the curve [AUC] for blood glucose 48 h following subcutaneous dosing) (53)

The intracellular fluorescence intensity of the Dil was quantified using the PerkinElmer Operetta CLS imaging system

Supplementary information General remarks, Supplementary Figs

2003 Feb