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Jacqueline Maya, M.D., from Massachusetts General Hospital-Mass General Brigham in Boston, and colleagues conducted a retrospective cohort study of 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025, to compare weight gain and pregnancy outcomes with and without exposure to GLP-1 RAs before or during early pregnancy

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A 6C potency may need to be repeated every 1 2 hours for a period to improve symptoms while an M potency may only have to be given once

It was approved by the FDA as a prescription medication for people with lipodystrophy

Notes: Higher doses compensate for reduced nasal bioavailability compared to injection