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Those with pre-existing conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or gastritis may be more prone to experiencing stomach upset from supplements generally, including B12 preparations

Choline is the major precursor of betaine, and it is used by the kidneys to maintain water balance and by the liver as a source of methyl-groups for methionine formation

IP3 may trigger the release of calcium ions (Ca2+) from intracellular stores, while DAG may activate protein kinase C (PKC)

Antidiabetic medicines such as metformin: Long-term use may reduce vitamin B12 absorption and increase the requirement for cyanocobalamin supplementation

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