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10.1073/pnas.83.18.7029 21 FeligP.WahrenJ.RafL

Multiple studies have reported that GLP-1R activation dampens pro-inflammatory signaling pathways (53,54) and studies have identified GLP-1R as a negative costimulatory molecule in T cells, suggesting that antagonism may relieve this suppression and enhance effector T cell [T helper 1 cell (Th1)-type] responses (26,38,39)

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In addition, in order to compare the pharmacological efficacy of the multi-agonists with the standard treatment, subgroups of animals were orally treated with a daily dose of metformin (300 mg/kg)