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Intravital imaging in tumor-bearing mice revealed that systemic thermal therapy (core temperature elevated to 39.5C 0.5C for 6 hours) activated an IL-6 trans-signaling program in the tumor blood vessels that modified the vasculature such that it could support enhanced trafficking of CD8+ effector/memory T cells (Tems) into tumors

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It enhanced the respiratory control ratio RCR and the rate of ADP phosphorylation

This shift appears to be influenced by a growing awareness of the benefits associated with GLP-1 receptor agonists, which are recognized for their efficacy in weight management and glycemic control

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