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Accordingly, in vitro and ex vivo studies have shown that exposure to saxagliptin (135, 136) but not sitagliptin (136), results in altered cardiac electrophysiology and is associated with impaired cardiomyocyte contractility
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PMID: 30763613
In addition to transporting nucleotide analogues, ABCG2 is a vital transporter in intestinal UA excretion ( Mutation Loci of the ABCG2 Gene To investigate ABCG2 gene mutations in hyperuricaemia patients, researching performed mutation analysis on all coding regions and intronexon boundaries of the ABCG2 gene in 90 Japanese patients with hyperuricaemia ( V12M , Q126X , Q141K , G268R , S441N , and F506SfsX4 ( Q141K , V12M , and Q126X is 31.9, 19.2, and 2.8% ( Q141K , which leads to risk of hyperuricaemia and gout (Wen et al., 2015
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