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Letters in Drug Design & Discovery
GLP-1 and GLP-1-based therapies: addressing beta-cell dysfunction in type 2 diabetes
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the compound 1 used in the patent is not easy to obtain (the synthesis steps are relatively more, the cost is higher) and has low purity (in the process of preparing the compound 1 from the compound 6 in the previous step, the N-succinimide is easily removed while the tert-butyl group is removed)
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