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GHS-R has the ability to form heterodimers with other GPCRs, such as dopamine receptors, melanocortin 3 receptors, and serotonin 2C receptors 26, 28, 29 , and these dimerizations alter the neuronal circuits of feeding behavior 26
Data extraction and outcome measures Data were extracted independently by two authors using a standardized form
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Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1