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& Hussain, N

Rahman I, Smith CA, Lawson MF, Harrison DJ, MacNee W: Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells

And, when the V max values are set to 10% of their normal values, the number of functional hepatocytes decreases to 10% of normal after 40 hours (the red curve), well below the grey bar marking 30% remaining hepatocytes, which is thought to be the threshold for liver failure[10]

In contrast, NAC, bearing a negative charge at physiological pH, demonstrates slower cellular uptake due to its N-acetyl group, which hinders both passive and active membrane transport