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Sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists have become cornerstone drug classes in the treatment of type 2 diabetes1516 owing to their cardiovascular and kidney benefits.17181920 Post hoc analyses of randomized trials have recently shown that SGLT-2 inhibitors also lower the risk of hyperkalemia compared with placebo, an outcome that was not defined as primary or secondary in those trials.212223 However, we do not know whether these benefits are also observed outside the highly controlled setting of randomized trials, and whether all agents within the SGLT-2 inhibitor class similarly reduce the risk of hyperkalemia

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