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Notably, SCFAs act as critical signaling metabolites that activate G-proteincoupled receptors (GPCRs), thereby suppressing pro-inflammatory cytokine production and promoting regulatory T-cell expansion within the colonic mucosa (301)
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1 Introduction Immune cells modify the metabolic pathways by which they generate energy to appropriately respond to sterile and infectious stimuli ( Immune cell activation and function are regulated by sex- and environmental-based factors
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