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Front Immunol (2021) 12:677550
DPP-4, an enzyme circulating freely in the blood, cleaves native GLP-1 at position 8 within about 90 to 120 seconds of release
Comparing Semaglutide and Tirzepatide While both semaglutide and tirzepatide are effective in managing obesity and type 2 diabetes, their mechanisms of action differ slightly: Semaglutide is a GLP-1 receptor agonist that primarily works by: - Slowing gastric emptying - Reducing appetite through brain signaling - Stimulating insulin release from the pancreas - Decreasing glucagon secretion Tirzepatide, on the other hand, is a dual GIP and GLP-1 receptor agonist, often referred to as a "twincretin"[8]
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