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doi: 10.1038/s41591-024-02813-1 99 OkabeSTanakaYGotohA

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Marihuana is listed in Schedule I of the CSA due to its high potential for abuse, which is attributable in large part to the psychoactive effects of THC, and the absence of a currently accepted medical use of the plant in the United States

The trapping mechanism implies that a blocker can enter the open ion channel followed by gate closure behind the blocker, thereby trapping it inside the ion channel pore until the channel is opened again

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