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This area of research may one day render unnecessary surgical interventions such as stenting, coronary artery bypass grafting, and more

Others have implied retatrutide may have more gastrointestinal side effects, but mileage varies

Plus, real-world adherence data from Blue Health Intelligence and a 2025 study in JAMA Network Open show that roughly 30 percent of patients discontinue within the first month and over half quit within three months with physical discomfort cited as a primary driver. However, with the exception of nausea, Carroll explains that what often tips a patient toward wanting to discontinue the medication isnt one severe symptom

Those with FTO or MC4R variants linked to appetite dysregulation may benefit from targeted dose adjustments or alternative compounds like tirzepatide, which activates both GLP-1 and GIP receptors

Treatment response durations varied, with Payne et al