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More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]
We also tested NSC636819 (NSC), an inhibitor of the H3K36me3 (and H3K9me3) demethylases KDM4A/KDM4B 46
OU749, a species-specific uncompetitive GGT inhibitor, exhibits low toxicity and a broad therapeutic window for humans
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