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Notably, about one in four of these patients did not carry a type 2 diabetes diagnosis , suggesting that a substantial portion of GLP-1 use is being driven by weight loss and other emerging indications outside of diabetes care (Figure 2)

It is important to acknowledge that the relationships we found between AC levels, MDD diagnosis, depression severity and depression profiles may be explained to some extent by shared distal environmental and lifestyle factors (e.g., comorbid somatic diseases, sedentary behavior, smoking, high-fat diet, alcohol consumption [61,62,63,64] that could act as confounder or mediators of the association

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Inhibition of RRM2 can reduce RRase activity, inhibit cancer cell growth, promote cancer cell apoptosis, prevent tumor metastasis and reverse drug resistance

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