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Supporting healthy GLP-1 levels can help with weight management and metabolic health
Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element
A randomized, double-blind, placebo-controlled phase 2 trial in Denmark involving 64 adults at high fracture risk found that once-weekly subcutaneous semaglutide did not increase the bone formation marker P-PINP relative to placebo, but did increase bone resorption and led to reductions in lumbar spine and hip BMD, tibial cortical thickness, and body weight over 52 weeks [104]
Oncogene 25 (16), 23042317
Compared with traditional small molecule antidiabetic drugs, peptide-based drugs modified from GLP-1 have a glucose concentration-dependent effect on stimulating insulin secretion
