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Safety of Taking Semaglutide Early: What the Evidence Shows Clinical trials that established semaglutide's safety and effectiveness used strict weekly schedules, so researchers didn't specifically test what happens when patients shift their timing by a single day

doi:10.1016/j.jacc.2025.04.059 Heinsen LJ, Pararajasingam G, Andersen TR, et al

A noticeable decline in strength, energy, food intake or function should be medically reviewed

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This makes carbs an important and beneficial part of a balanced diet