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found another degradation mechanism of TAGs in LDs, referred to as lipophagy, which is the primary lipid removal pathway in the liver [75], and was subsequently also found in neurons, macrophages, and tumor cells
DOI: 10.1016/j.jacc.2017.03.003
Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]
Human data: Human data comprises pharmacokinetic/pharmacodynamic study in volunteers and a completed Phase II trial for postoperative ileus (NCT00672074)
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