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It should not be used as a drug or injection, since the FDA has not approved it for human use

If you carry more body fat over your chosen injection site, you may need a 1.5-inch needle for a true intramuscular shot

But theres a pattern to who tends to seek it out and who may be a reasonable candidate after a proper evaluation

(October 18, 2025) Evaluation of Polmacoxib 2 mg for the Management of Hip and Knee Osteoarthritis: A Prospective, Single-Arm, Multicenter, Open-Label Study

For one thing, she says, the way a peptide is synthesized for research purposes (with a so-called TFA salt) is different and arguably makes it more toxic than an FDA-approved peptide formulated for human use