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Most of the drugs used for general anesthesia are metabolized through the liver, kidneys, and to a lesser extent through the lungs
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With their intentional nonadherence to oral medications leading to multiple recurrent relapses, these patients are at serious risk for neuroprogression and brain atrophic changes driven by multiple factors: inflammatory cytokines, increased cortical steroids, decreased neurotrophins, deceased neurogenesis, increased oxidative stress, and mitochondrial energy dysfunction
Systematic review of the effects of exercise and physical activity on the gut microbiome of older adults
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