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Science 335 , 15031506 (2012)
Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence
The LR3 signifies a modification with an extended N-terminus and the substitution of an Arginine for a Glutamic acid, which dramatically increases its biological half-life and prevents it from being bound by IGF-binding proteins.
doi: 10.1016/j.diabet.2018.09.005 154 TeramiNOgawaDTachibanaHHatanakaTWadaJNakatsukaAet al
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