In these patients, administration of an NSAID may cause a dose-dependant reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal failure
Potential side effects include hives and allergic reactions
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Cobalamins are complex cobalt-containing tetrapyrrole molecules, in which various forms differ in the nature of the upper axial ligand (e.g., methyl, cyano, hydroxyl or adenosyl) that is ligated to the central Co atom
(PubMed) McCleery J, Abraham RP, Denton DA, et al