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PT-141 Research Applications PT-141 is used in vitro as an MC4R-preferring reference agonist at the human melanocortin receptors, and as a structure-activity probe of the C-terminus

Published in The Journal of Clinical Endocrinology & Metabolism , the study documents a short systemic half-life for the tetra-substituted GRF(129) sequence (~30 minutes), predictable dose proportionality and physiologic pulsatile GH release in response to a single SC dose

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