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Cell Metab 2022;34:123447.ArticlePubMed 63

Central nervous system Several Sikiric studies have reported neuroprotective effects in models of stroke, spinal cord injury, and neuroinflammation

Gastrointestinal side effects observed under cotadutide effects are similar in quality but more severe than those under GLP-1RA treatment ( Animal data on a GLP-1/GIP/glucagon triple agonist show strong effects on body weight reduction, and glucose- and lipid normalization in rodents

The Gene Expression Paradox refers to the observation that BPC-157 is cleared from systemic circulation in approximately 15 minutes (mean elimination half-life in rats), yet its reparative effects persist for weeks

Results vary based on starting weight, diet, exercise, and adherence