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RGCs are vulnerable to mitochondrial damage as the enrichment of mitochondria colonization, and have a rapid metabolism and high energy dependence (Shi et al., 2014)

Additionally, diabetes-related emotional distress and depression symptom severity have been identified as risk factors for medication non-adherence in T2DM [136, 137]

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One systematic review found that semaglutide protected the blood-brain barrier, which is responsible for stopping toxins, pathogens (substances that cause disease) and other harmful substances from leaking into the brain

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