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The pivotal STEP (Semaglutide Treatment Effect in People with obesity) clinical trials, which enrolled over 4,500 participants, did not identify iron deficiency as a significant safety concern

These changes help the body produce and use energy more efficiently, reducing fatigue over time

How GLP-1s Work GLP-1s mimic a hormone produced in the small intestine that increases the sensitivity to the insulin your body produces, decreasing the amount of hunger hormone your body makes

Oral GLP-1 receptor monoagonists: semaglutide, orforglipron and danuglipron Oral semaglutide is formulated as a tablet with an absorption enhancer that facilitates its passage through the gastric mucosa

This means tirzepatide clears from your system somewhat faster, taking about 3 to 4 weeks for complete elimination compared to semaglutides 5 weeks