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They make lower doses more effective and higher doses more tolerable

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However, at doses above the saturation threshold (approximately 1 mcg/kg), GHRP-6 stimulates adrenocorticotropic hormone (ACTH) release, leading to elevated cortisol, and increases prolactin secretion from lactotroph cells

It may influence sleep-related signaling, circadian rhythms, and stress pathways in experimental models, though findings are limited to preclinical and in vitro studies