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Bkdal TA, Borregaard J, Donsmark M, et al

How GLP-2 Works GLP-2 binds to GLP-2 receptors (GLP-2R) found primarily in the gastrointestinal tract, specifically on: Intestinal epithelial cells Enteric neurons Subepithelial myofibroblasts This targeted action makes GLP-2 the bodys primary regulator of intestinal health and function

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This risk is compounded in patients already on anticoagulants (warfarin, apixaban) or antiplatelet agents (aspirin, clopidogrel), making acetaminophen and topical pain relief much safer choices during GLP-1 therapy