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Although GLP-1 receptor agonists do not completely eliminate dopamine function, these medications appeared to reduce substance-induced dopamine activity without consistently suppressing baseline dopamine signaling

With those caveats in place, here is what the data and community sources describe at each phase

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In Phase 2 trials, participants lost up to 24% of their total body weight over 48 weeks at higher doses more than with any other GLP-based medication so far

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