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Rather than stopping the GLP-1RA abruptly, clinicians should consider a temporary dose reduction while awaiting objective laboratory results
The real key is going to be side effects over time, if retatrutide is like other drugs in the class then the side effects should decrease with time, but unfortunately, we dont have that today, at this point I have some questions and minor concerns but without the data over time its hard to speculate about tolerability further beyond saying its similar to other drugs in the class
Some people decide to stop taking GLP-1s when their weight loss plateaus or they are satisfied with their outcomes
Some patients develop gallbladder problems, including gallstones or even gallbladder inflammation (cholecystitis), during treatment
GLP-1 receptor activation suppresses appetite, slows gastric emptying, and promotes insulin secretion in a glucose-dependent manner
