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11 John Cronin, MD, senior vice president of clinical development at Apnimed, underscores the need for diverse treatment options
Still, it may be relevant to perform pilot studies to address whether the therapy will benefit selected HFrEF cohorts with obesity.
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Promising avenues include targeting tau pathology, neuroinflammation, mitochondrial dysfunction, brain insulin resistance, vascular integrity, and infectious triggers
These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane
