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Gangwar et al., 2025) (Figures 6A,B)

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CJC-1295 is a GHRH analog that targets growth hormonereleasing hormone pathways and supports natural growth hormone production

Supports Fat Loss & Lean Muscle Growth: By stimulating growth hormone, Ipamorelin helps increase fat metabolism while supporting lean muscle development

These simulations indicate that the ECD in the apo-state GLP-1R is quite dynamic and that the TMD-interacting closed conformations are energetically favorable in the absence of the peptide agonist