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Once Melanotan II binds melanocortin receptors in melanocytes and downstream signaling kicks in, the biological cascadeupregulated melanin synthesis, packaging in melanosomes, and transfer to keratinocytescontinues well after the peptide level falls

Journal of the International Society of Sports Nutrition , 14 , 18

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Measuring cell type-specific Ca 2+ dynamics in VTA neurons during cocaine reinstatement To identify the midbrain mechanisms underlying the efficacy of exendin-4 on cocaine seeking, transgenic rats expressing Cre recombinase under the Gad1 or Th promoter were implanted with indwelling jugular catheters as described above