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Changes to the microbial phyla and genera observed in the 5A-1MQ-treated group switched from WD to LD could have been driven by additive, synergistic, or independent mechanisms relative to those induced by diet switch alone, which could not be determined with the current study design that lacked a group treated with 5A-1MQ and maintained on WD

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A committee recommended, against its own agencys technical advice, that a group of compounds with little completed human trial data be made available through a regulated prescription channel

It is important to note that most of these effects have been observed in animal studies, and human clinical trials are currently very limited

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