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The pro-autophagic effect of IGFBPs is also reflected in processes such as chemoresistance in hepatocellular carcinoma (59)

DOI: 10.3390/molecules28031447

However, this typically requires ongoing treatment to maintain

For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

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