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Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus in adults (Mounjaro) and chronic weight management (Zepbound) in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
Several candidates are advancing through clinical development, including orforglipron, currently in Phase III trials for obesity and type 2 diabetes
A top pQTL is the top (most significantly associated) variant per megabase bin
Thats the headline result of a new clinical trial that tested the popular medication in patients with MASH, or metabolic dysfunction-associated steatohepatitis
This study established the connection between enlarged naevi and melanoma risk, which led to the concept of dysplastic naevi as precursor lesions to melanoma
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