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The single best reason to take a vitamin B12 supplement is to prevent vitamin B12 deficiency which can lead to a number of symptoms and even long-term health issues, such as chronic fatigue, mood disorders, neurodegenerative disorders, heart issues, anemia and neural tube defects in infants

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If you find yourself experiencing these symptoms often you may need to talk to your healthcare provider about the potential of having a vitamin B12 deficiency

These include situations where metformin is ineffective, contraindicated, or when patients fail to reach their target glycemic control despite treatment with metformin and other medications

This finding raised Li's suspicions about B12's role in acne, she said