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Thats because APD is due to progesterone hypersensitivityand progesterone is highest before a womans period starts

2), 16,17 many of these studies have focused on the relevance of glutamate, mainly in the central nervous system, describing a correlation between increased glutamate efflux and increased cancer aggressiveness and invasive capacity (and, consequently, poor prognosis)

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doi: 10.3389/fimmu.2026.1630969 Received 19 May 2025 Revised 07 February 2026 Accepted 09 February 2026 Published 27 February 2026 Volume 17 - 2026 Edited by Pablo Andres Evelson, University of Buenos Aires, Argentina Reviewed by Huanling Lai, Guangzhou National Laboratory, China Neelima Sharma, Birla Institute of Technology and Science, India Updates Copyright 2026 Ni, Chen, Jiang and Huang

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