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Proc Natl Acad Sci U S A 111(11):40014006
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An updated systematic review and network meta-analysis of GLP-1 receptor agonists and polyagonists ranked retatrutide at or near the top for weight loss among the modern agents, while also flagging that the strongest-effect agents tend to carry the highest adverse-event burden
Common goals include weight loss, muscle recovery, improved sleep, enhanced energy, skin rejuvenation, hormone balance, and gut health
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