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FIGURE 4 4.5 Inhibition of glucagon release Considered an anti-insulin hormone, 2022 marks the 100th anniversary of the discovery of glucagon, which is produced in islet cells through the processing of prohormone-converting enzyme 2 (Pcsk2) and acts through glucagon receptor (GCGR) (Hayashi, 2011)

Stable gastric pentadecapeptide BPC 157, Robert's stomach cytoprotection/adaptive cytoprotection, and Selye's stress coping response

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Read More: Bulimia Nervosa: Decoding the Intricacies of Binge and Purge Impact of binge eating disorder The reviews papers consistently showed GLP-1 RAs lessened common symptoms of BED, such as frequency of binge episodes and losing the ability to control ones eating

Pharma is innovating to hit even more targets The latest article I saw about the work being done in this class is a study in mice looking at a quintuple agonist (5 different targets!) I almost never write about mice studies because of how preliminary they are and how unlikely a finding in mice is to ever translate into anything useful in humans, but because of the success weve already seen of this drug class as well as the way that hitting more pathways seems to increase efficacy, I thought this was research worth highlighting