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The peptides will still bind to their receptors, but the downstream cascade they're designed to trigger gets suppressed at multiple points in the pathway

Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations

*Correspondence: Chao Liang, [email protected] These authors have contributed equally to this work This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

reaction 7 product) is also identified as 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide and also as succinylaminoimidazole carboxamide ribotide

Manuscript preparations: NC, EM, ENK