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Gastrointestinal side effects are the most commonly reported and include: Nausea (affecting 1040% of patients, depending on the specific GLP-1 agonist) Vomiting and diarrhoea (less common than nausea but can contribute to dehydration) Constipation (due to slowed gastric emptying) Abdominal discomfort or bloating These effects are typically most pronounced during treatment initiation and following dose increases

For how the research on GLP-1s and mood is shaping up more broadly, see our post on GLP-1 medications and mental health

Most cells contain numerous SAMe-dependent methyltransferases that can transfer the methyl group (CH 3 ) to all varieties of key substrates, for example nucleic acid, protein, phospholipids, and monoamine neurotransmitters [4]

The key to their success was introducing a range of behavioural changes (nearly twice as much versus behavioural changes alone)

Weekly dosing may improve adherence for some patients compared to daily injectable or oral diabetes medications