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In particular, we substantiated that high levels of Bcl-2 leads to increased amount of GSH and finally impair virus infection (Nencioni et al., 2003)

Regarding the underlying mechanism, IR in the brain significantly contributes to neurodegenerative processes, and GLP-1RAs modulate downstream signaling pathways, including mitochondrial biogenesis, autophagy, inflammation, and cell survival

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The FDA's standard review period for a Priority Review designation is six months