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This impairment can lead to neuronal damage and increased A accumulation, a key feature of AD pathology [14, 15]

In a study of 1,961 patients assigned to take either semaglutide or placebo for 68 weeks, 86.4% of the patients on semaglutide achieved at least 5% weight loss

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Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses

2020 Jan 20, Volume 12 (Issue 2), Pages 12721284