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When combined with metformin, outcomes may improve further in selected patients

The delivery methods also differ considerably - while injections provide controlled, consistent release of medication through subcutaneous administration, patches rely on unproven transdermal delivery that cannot effectively transport the hormone through the skin barrier

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SGLT2 inhibitors (dapagliflozin and empagliflozin) reduce HbA1c (about 24 mmol/L), body weight (12 kg), and the total required insulin dose compared to placebo [64, 65]

That kind of transparency changes the conversation, moving us beyond simplistic before-and-after narratives