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First, leptin increases the transcription of the Bdnf gene in proestrus but not diestrus, with specific changes in expression of exons I, II, III, and VI

Inflammation-associated cytokine signaling (e.g., IL-1, TNF-) can suppress the GnRH drive by interfering with the kisspeptin-GnRH neuronal network, thereby disrupting LH/FSH secretion (particularly destroying the pulsatile rhythm of LH) (133, 134)

moreover, the ability of -glutamylcysteine to induce protein modification is well below that of GSH