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March 16, 2023 AMA #45: Pros And Cons Of GLP-1 Weight Loss Drugs And Metformin As Geroprotective Agent | The Drive with Peter Attia #246 Check out The Drive episode page Key Takeaways GLP-1 and GIP both started as drugs to control glucose and insulin resistance in people developing or with type 2 diabetes Studies showed the added benefit of GLP-1 agonists on weight loss but the mechanism is unclear, though they do reduce appetite in some way Introduction In this special episode of The Drive, Peter focuses the discussion on two topics getting a lot of attention recently: GLP-1 agonists for weight loss and metformin for longevity
Her family isn't alone: The KFF Health Tracking Poll estimated in June 2024 that one in eight Americans either take or has taken one of these medications
No serious adverse events were reported in the limited human data available as of 2026, but the sample sizes are insufficient for definitive safety conclusions
Whether your provider recommends a weight loss injection like Zepbound or the oral option like the Wegovy pill, each treatment plan is tailored to your health goals and insurance coverage
Some Anthem plans cover Zepbound under its sleep apnea indication even if they exclude weight loss medications
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