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The result is noticeable puffiness that feels like something has gone wrong but is actually a normal physiological response to sodium fluctuation
Probiotics may help restore gut balance
Locke M, Heywood M, Fawell S, Mackenzie IC
Nadolsky says that for some of his patients at the highest dose of tirzepatide, the drug is sometimes "dampening that dopamine reward system down so much that now, instead of just getting away from those addictive behaviors, they don't feel like doing anything." Some of those high-dose patients start seeking out sugar, not due to cravings, he says, but because their bodies are searching for some kind of stimulation to get the reward system going again
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